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Discussion A prevailing dogma is that a major fate of cysteine is its incorporation into the antioxidant GSH

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Recently, Zajac and collaborators (Zajac et al., 2024) provided an unequivocal demonstration of the importance of TMEM165 in intracellular pH dynamics by acting as a proton-activated, lysosomal Ca 2+ importer in several cell types (i.e., Saccharomyces cerevisiae strain that lacks both the vacuolar Ca 2+ importers, pmc1 and vcx1, and expresses HsTMEM165 and HeLa cells where HsTMEM165 was either knocked out or overexpressed)